This is a drug which works against irregularly irregular heart rhythms by increasing positive inotropic and negative chronotropic effects.

This drug if mixed with Amiodarone may cause toxicity which can result in ventricular tachy-arrhythmias. Should this drug be mixed with Amiodarone, typically the dosage needs to be reduced by 50% to observe the interaction.

This drug relies on normal serum potassium levels in order to function normally. With lowered levels of potassium, signs of toxicity increases. This makes potassium sparing diuretics such as spironolactone the drug of choice when it comes to patients with heart failure. Excess of this drug, may result in AV blocks, SA Blocks and dangerous rhythms such as ventricular tachycardia and fibrillation.

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